Deficient regulatory B cells in human chronic graft-versus-host disease.
Fiche publication
Date publication
juillet 2015
Journal
Oncoimmunology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BENSUSSAN Armand
Tous les auteurs :
de Masson A, Socié G, Bagot M, Bensussan A, Bouaziz JD
Lien Pubmed
Résumé
Human chronic graft-versus-host disease (cGVHD) is a frequent and disabling complication of allogeneic hematopoietic stem cell transplantation. Regulatory B cells (Bregs) are IL-10-producing B cells that are able to inhibit the innate and adaptive immune responses. We have recently demonstrated a defect in regulatory B cells in human cGVHD.
Mots clés
allogeneic stem cell transplantation, chronic graft-versus-host disease, interleukin-10, regulatory B cells
Référence
Oncoimmunology. 2015 07;4(7):e1016707