[Immunopathology of psoriasis: from bench to bedside].
Fiche publication
Date publication
mars 2016
Journal
Medecine sciences : M/S
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BENSUSSAN Armand
Tous les auteurs :
de Masson A, Bouaziz JD, Battistella M, Bagot M, Bensussan A
Lien Pubmed
Résumé
Psoriasis is a frequent inflammatory disease that involves mostly the skin and sometimes the joints. This chronic disease is rarely life-threatening but impairs significantly the patient's quality of life. It is characterized, in its typical form, by erythematous and squamous plaques with well-defined borders, associated with increased proliferation of the keratinocytes, inflammation and greater number of dilated blood vessels in the upper dermis. A role of Th1 CD4 T cells was initially suspected. More recently, Th17 CD4 T cells have been shown to play a major role in the disease. It has led to the development of Th17 inhibitors, such as anti-IL-23 (cytokine that induces Th17 CD4 T cell differentiation), anti-IL-17, anti-IL-17RA (IL-17 receptor) and anti-IL-22 (cytokines that are notably produced by Th17 CD4 T cells).
Mots clés
Animals, CD4-Positive T-Lymphocytes, immunology, Cell Differentiation, immunology, Humans, Langerhans Cells, immunology, Psoriasis, diagnosis, Skin, cytology, Th17 Cells, immunology
Référence
Med Sci (Paris). 2016 03;32(3):253-9