Increased expression of PD1 and CD39 on CD3 CD4 skin T cells in the elderly.
Fiche publication
Date publication
janvier 2019
Journal
Experimental dermatology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BENSUSSAN Armand
Tous les auteurs :
Zuelgaray E, Boccara D, Ly Ka So S, Boismal F, Mimoun M, Bagot M, Bensussan A, Bouaziz JD, Michel L
Lien Pubmed
Résumé
Normal ageing is associated with an impaired systemic immune response contributing to an increased susceptibility to infectious diseases. The aim of this study was to compare the lymphocyte phenotype in human skin from old and young healthy subjects. Skin samples from donors were used for explant cultures before flow cytometric analysis. Our results depicted a higher proportion of CD4 and a lower proportion of CD8 among CD3 T cells, a decreased proportion of CD45RA naive T cells (3.5 ± 1.9% vs 22.9 ± 11.1%, P ≤ 0.007) and an upregulation of the expression of CD39 and PD1 on CD3 CD4 T cells (25.1 ± 8.5% vs 12.5 ± 8.5%, P ≤ 0.003, 68.8 ± 11.6% vs 50.0 ± 11.3%, P ≤ 0.01, respectively) in the skin of old subjects. These findings could explain a reduced generation of long-lived memory T cells and an impaired antitumoral response in the skin of the elderly.
Mots clés
PD1 inhibitory marker, ageing, ecto-nucleotidase CD39, skin T cells, skin innate lymphoid cells
Référence
Exp Dermatol. 2019 01;28(1):80-82