High-frequency oscillations and spikes running down after SEEG-guided thermocoagulations in the epileptogenic network of periventricular nodular heterotopia.
Fiche publication
Date publication
février 2019
Journal
Epilepsy research
Auteurs
Membres identifiés du Cancéropôle Est :
Pr PROUST François
Tous les auteurs :
Scholly J, Pizzo F, Timofeev A, Valenti-Hirsch MP, Ollivier I, Proust F, Roehri N, Bénar CG, Hirsch E, Bartolomei F
Lien Pubmed
Résumé
Epilepsy associated with periventricular nodular heterotopia (PNH) is characterized by complex relationships between the heterotopic and the normotopic cortex during the interictal state and at seizure onset. High-frequency oscillations (HFO) have been proposed as a marker of epileptogenicity that might reflect disease activity. The effects of thermocoagulations on epileptogenicity in this context remain unknown. We aimed to investigate the interictal HFO- and spike profiles of different cortical structures before and after two consecutive SEEG-guided thermocoagulations, in correlation with seizure outcome, in a patient with PNH-related drug-resistant epilepsy.
Mots clés
Epileptogenicity, High-frequency oscillations, Periventricular nodular heterotopia, SEEG, Thermocoagulations
Référence
Epilepsy Res. 2019 02;150:27-31