Response to Chemoimmunotherapy Is Associated With Expansion of Systemic Antitumor CD4+ Th1 Response in Metastatic Non-Small Cell Lung Cancer.
Fiche publication
Date publication
février 2023
Journal
Journal of immunotherapy (Hagerstown, Md. : 1997)
Auteurs
Membres identifiés du Cancéropôle Est :
Pr ADOTEVI Olivier, Mme LAHEURTE Caroline
Tous les auteurs :
Wespiser M, Marguier A, Lecoester B, Richard T, Boullerot L, Malfroy M, Kumar A, Laheurte C, Adotévi O
Lien Pubmed
Résumé
Limited data have reported the evolution of antitumor immune responses under chemoimmunotherapy (chemo-IO) in patients with metastatic non-small cell lung cancer. In this concise study, we performed dynamic monitoring of antitumor CD4+ T helper 1 (Th1) response in peripheral blood from 12 patients receiving a first-line chemo-IO. Tumor-reactive CD4+ Th1 cells were assessed within blood lymphocytes using interferon-gamma enzyme-linked immunospot assay to detect telomerase (TERT)-specific T cells at baseline, 3 and 12 months after treatment. An induction of circulating anti-TERT CD4+ Th1 response were found in 6 of 12 patients at 3 months after chemo-IO. In contrast, 3 patients had a substantial decrease in their preexisting response and 3 remained nonimmune responders. Among patients with chemo-IO-induced immune response, half achieved an objective clinical response and had long-lasting circulating anti-TERT CD4+ Th1 cells detected for at least 1 year. In contrast, no objective response was documented in nonimmune responders and a link between the loss of anti-TERT CD4+ Th1 responses were observed in patients with progressive disease. This preliminary work supports a relationship between the efficacy of combinatorial chemo-IO and circulating anti-TERT CD4+ Th1 responses and highlights the interest to implement blood-based monitoring of tumor-reactive CD4+ T cells that could be additional help for patient management.
Référence
J Immunother. 2023 02 20;: