Do proton pump inhibitors alter the response to immune checkpoint inhibitors in cancer patients? A meta-analysis.
Fiche publication
Date publication
janvier 2023
Journal
Frontiers in immunology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MASCAUX Céline, Dr DORY Anne
Tous les auteurs :
Lopes S, Pabst L, Dory A, Klotz M, Gourieux B, Michel B, Mascaux C
Lien Pubmed
Résumé
Gut microbiota can significantly affect the effectiveness of immune checkpoint inhibitors (ICIs) in cancer patients. Recently, antibiotics were shown to decrease survival rate of patients treated by ICIs. Proton pump inhibitors (PPIs) can indeed modulate microbiota's diversity, therefore altering ICIs response. A meta-analysis was performed based on published data to verify this hypothesis.
Mots clés
immune checkpoint inhibitors, meta – analysis, proton pump inhibitors, solid cancer, survival
Référence
Front Immunol. 2023 01 26;14:1070076