18FDG PET/CT Tumoral and Neurologic Therapeutic Response in a Case of Anti-GABABR Paraneoplastic Limbic Encephalitis.
Fiche publication
Date publication
mars 2023
Journal
Clinical nuclear medicine
Auteurs
Membres identifiés du Cancéropôle Est :
Dr MENNECIER Bertrand, Pr NAMER Izzie-Jacques
Tous les auteurs :
Ouvrard E, Voulleminot P, Mennecier B, Bund C, Namer IJ
Lien Pubmed
Résumé
A 70-year-old man with a history of small cell lung carcinoma 2 years earlier was addressed for the suspicion of a paraneoplastic limbic encephalitis. Brain 18FDG PET/CT revealed a bilateral amygdalian and hippocampal hypermetabolism, confirming a limbic encephalitis, and concurrent whole-body 18FDG PET/CT showed a small cell lung carcinoma plurifocal metastatic recurrence, consistent with a paraneoplastic limbic encephalitis. 18FDG PET/CT follow-up under chemotherapy revealed an almost complete normalization of brain metabolism and a partial metabolic response of the metastatic recurrence, consistent with the good clinical neurological evolution of the patient. This case highlights the clinical-metabolic imaging correlation in paraneoplastic limbic encephalitis.
Mots clés
Male, Humans, Aged, Limbic Encephalitis, complications, Small Cell Lung Carcinoma, complications, Positron Emission Tomography Computed Tomography, Fluorodeoxyglucose F18, Lung Neoplasms, complications
Référence
Clin Nucl Med. 2023 03 1;48(3):237-239