[Comparative cost analysis of molecular biology methods in the diagnosis of sarcomas].
Fiche publication
Date publication
octobre 2013
Auteurs
Lien Pubmed
Résumé
Sarcomas represent a complex and heterogeneous group of rare malignant tumors and their correct diagnosis is often difficult. Recent molecular biological techniques have been of great diagnostic use and there is a need to assess the cost of these procedures in routine clinical practice. Using prospective and observational data from eight molecular biology laboratories in France, we used "microcosting" method to assess the cost of molecular biological techniques in the diagnosis of five types of sarcoma. The mean cost of fluorescence in situ hybridization (FISH) was 318 euro (273-393) per sample; mean reverse transcription polymerase chain reaction (RT-PCR) cost ranged from 300 euro (229-481) per formalin-fixed, paraffin-embedded specimen to 258 euro (213-339) per frozen specimen; mean quantitative polymerase chain reaction (Q-PCR) cost was 184 euro (112-229) and mean CGH-array cost was 332 euro (329-335). The cost of these recently implemented techniques varied according to the type of sarcoma; the method of tissue collection and local organizational factors including the level of local expertise and investment. The cost of molecular diagnostic techniques needs to be balanced against their respective performance.
Référence
Bull Cancer. 2013 Oct;100(10):963-71