Acute toxicities and cumulative dose to the brain of repeated sessions of stereotactic radiotherapy (SRT) for brain metastases: a retrospective study of 184 patients.
Fiche publication
Date publication
janvier 2023
Journal
Radiation oncology (London, England)
Auteurs
Membres identifiés du Cancéropôle Est :
Pr ANTONI Delphine, Pr NOEL Georges, Dr CEBULA Hélène, Dr LE FEVRE Clara
Tous les auteurs :
Kuntz L, Le Fèvre C, Jarnet D, Keller A, Meyer P, Thiery A, Cebula H, Noel G, Antoni D
Lien Pubmed
Résumé
Stereotactic radiation therapy (SRT) is a focal treatment for brain metastases (BMs); thus, 20 to 40% of patients will require salvage treatment after an initial SRT session, either because of local or distant failure. SRT is not exempt from acute toxicity, and the acute toxicities of repeated SRT are not well known. The objective of this study was to analyze the acute toxicities of repeated courses of SRT and to determine whether repeated SRT could lead to cumulative brain doses equivalent to those of whole-brain radiotherapy (WBRT).
Mots clés
Acute toxicity, Brain metastases, Repeated radiosurgery, Salvage radiation, Side effect, Stereotactic radiosurgery
Référence
Radiat Oncol. 2023 01 10;18(1):7