Canonical and non-canonical functions of NLRP3.
Fiche publication
Date publication
janvier 2023
Journal
Journal of advanced research
Auteurs
Membres identifiés du Cancéropôle Est :
Dr VEGRAN Frédérique
Tous les auteurs :
Accogli T, Hibos C, Vegran F
Lien Pubmed
Résumé
Since its discovery, NLRP3 is almost never separated from its major role in the protein complex it forms with ASC, NEK7 and Caspase 1, the inflammasome. This key component of the innate immune response mediates the secretion of proinflammatory cytokines IL-1β and IL-18 involved in immune response to microbial infection and cellular damage. However, NLRP3 has also other functions that do not involve the inflammasome assembly nor the innate immune response. These non-canonical functions have been poorly studied. Nevertheless, NLRP3 is associated with different kind of diseases probably through its inflammasome dependent function as through its inflammasome independent functions.
Mots clés
NLRP3, inflammasome, myeloid cells, uncanonical functions
Référence
J Adv Res. 2023 01 4;: