Understanding the interactions of Guanine-Quadruplexes with peptides as novel strategies for diagnosis or tuning biological functions.
Fiche publication
Date publication
janvier 2023
Journal
Chembiochem : a European journal of chemical biology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GRANDEMANGE Stéphanie
Tous les auteurs :
Miclot T, Froux A, D'Anna L, Bignon E, Grandemange S, Barone G, Monari A, Terenzi A
Lien Pubmed
Résumé
Guanine quadruplexes (G4s) are nucleic acid structures exhibiting a complex structural behavior and exerting crucial biological functions, in both cells and viruses. The specific interactions of peptides with G4s, as well as the understanding of the factors driving the specific recognition, are important for the rational design of both therapeutic and diagnostic agents. In the present minireview, we examine the most important studies dealing with the interactions between G4s and peptides, highlighting the strengths and limitations of the present analytic approaches. We also show how the combined use of high-level molecular simulation techniques and experimental spectroscopy represents the best avenue to achieve the design of specifically tuned and selective peptides, thus leading to the control of important biological functions.
Mots clés
DNA and RNA, Guanine Quadruplexs, Molecular Modeling and Simulation, Peptide, Spectroscopy
Référence
Chembiochem. 2023 01 4;: