Biosensors for the Rapid Detection of Cardiovascular Biomarkers of Vital Interest: Needs, Analysis and Perspectives.
Fiche publication
Date publication
novembre 2022
Journal
Journal of personalized medicine
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GOETZ Christophe
Tous les auteurs :
Abensur Vuillaume L, Frija-Masson J, Hadjiat M, Riquier T, d'Ortho MP, Le Borgne P, Goetz C, Voss PL, Ougazzaden A, Salvestrini JP, Leïchlé T
Lien Pubmed
Résumé
We have previously surveyed a panel of 508 physicians from around the world about which biomarkers would be relevant if obtained in a very short time frame, corresponding to emergency situations (life-threatening or not). The biomarkers that emerged from this study were markers of cardiovascular disease: troponin, D-dimers, and brain natriuretic peptide (BNP). Cardiovascular disease is a group of disorders affecting the heart and blood vessels. At the intersection of medicine, basic research and engineering, biosensors that address the need for rapid biological analysis could find a place of choice in the hospital or primary care ecosystem. Rapid, reliable, and inexpensive analysis with a multi-marker approach, including machine learning analysis for patient risk analysis, could meet the demand of medical teams. The objective of this opinion review, proposed by a multidisciplinary team of experts (physicians, biologists, market access experts, and engineers), is to present cases where a rapid biological response is indeed valuable, to provide a short overview of current biosensor technologies for cardiac biomarkers designed for a short result time, and to discuss existing market access issues.
Mots clés
BNP, D-dimers, biosensors, cardiac biomarkers, troponin
Référence
J Pers Med. 2022 11 22;12(12):