[Mecanisms of pharmacokinetic interactions involving oral anticancer agents].
Fiche publication
Date publication
janvier 2015
Journal
Bulletin du cancer
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DORY Anne
Tous les auteurs :
Levêque D, Duval C, Poulat C, Palas B, El Aatmani A, Dory A, Becker G, Gourieux B
Lien Pubmed
Résumé
Oral anticancer agents and particularly kinase inhibitors are subject to pharmacokinetic drug interactions in relation to absorption and elimination phases. Interacting factors are food, fruit juices, cigarette smoke, acid-reducing agents and inducers/inhibitors. Some anticancer agents are inducers and/or inhibitors and can also perpetrate drug interactions. This review emphasizes the mechanisms of pharmacokinetic drug interactions involving oral anticancer agents.
Mots clés
Agents anticancéreux oraux, Drug interaction, Interaction médicamenteuses, Oral anticancer agents, Pharmacocinétique, Pharmacokinetics
Référence
Bull Cancer. 2015 01;102(1):65-72