The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein.
Fiche publication
Date publication
juillet 2016
Journal
Oncotarget
Auteurs
Membres identifiés du Cancéropôle Est :
Dr NARDIN Charlée
Tous les auteurs :
Ramos-Espiritu L, Diaz A, Nardin C, Saviola AJ, Shaw F, Plitt T, Yang X, Wolchok J, Pirog EC, Desman G, Sboner A, Zhang T, Xiang J, Merghoub T, Levin LR, Buck J, Zippin JH
Lien Pubmed
Résumé
cAMP signaling pathways can both stimulate and inhibit the development of cancer; however, the sources of cAMP important for tumorigenesis remain poorly understood. Soluble adenylyl cyclase (sAC) is a non-canonical, evolutionarily conserved, nutrient- and pH-sensing source of cAMP. sAC has been implicated in the metastatic potential of certain cancers, and it is differentially localized in human cancers as compared to benign tissues. We now show that sAC expression is reduced in many human cancers. Loss of sAC increases cellular transformation in vitro and malignant progression in vivo. These data identify the metabolic/pH sensor soluble adenylyl cyclase as a previously unappreciated tumor suppressor protein.
Mots clés
cAMP, metabolic sensor, microdomain, sAC, tumor suppressor
Référence
Oncotarget. 2016 07 19;7(29):45597-45607