Genetic and Pharmacological Inhibition of TREM-1 Limits the Development of Experimental Atherosclerosis.
Fiche publication
Date publication
décembre 2016
Journal
Journal of the American College of Cardiology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr POTTEAUX Stéphane
Tous les auteurs :
Joffre J, Potteaux S, Zeboudj L, Loyer X, Boufenzer A, Laurans L, Esposito B, Vandestienne M, de Jager SC, Hénique C, Zlatanova I, Taleb S, Bruneval P, Tedgui A, Mallat Z, Gibot S, Ait-Oufella H
Lien Pubmed
Résumé
Innate immune responses activated through myeloid cells contribute to the initiation, progression, and complications of atherosclerosis in experimental models. However, the critical upstream pathways that link innate immune activation to foam cell formation are still poorly identified.
Mots clés
apolipoprotein, foam cells, inflammation, macrophage, toll-like receptor
Référence
J Am Coll Cardiol. 2016 12 27;68(25):2776-2793