The Dendritic Cell Receptor DNGR-1 Promotes the Development of Atherosclerosis in Mice.
Fiche publication
Date publication
juillet 2017
Journal
Circulation research
Auteurs
Membres identifiés du Cancéropôle Est :
Dr POTTEAUX Stéphane
Tous les auteurs :
Haddad Y, Lahoute C, Clément M, Laurans L, Metghalchi S, Zeboudj L, Giraud A, Loyer X, Vandestienne M, Wain-Hobson J, Esposito B, Potteaux S, Ait-Oufella H, Tedgui A, Mallat Z, Taleb S
Lien Pubmed
Résumé
Necrotic core formation during the development of atherosclerosis is associated with a chronic inflammatory response and promotes accelerated plaque development and instability. However, the molecular links between necrosis and the development of atherosclerosis are not completely understood. Clec9a (C-type lectin receptor) or DNGR-1 (dendritic cell NK lectin group receptor-1) is preferentially expressed by the CD8α subset of dendritic cells (CD8α DCs) and is involved in sensing necrotic cells. We hypothesized that sensing of necrotic cells by DNGR-1 plays a determinant role in the inflammatory response of atherosclerosis.
Mots clés
DNGR-1, atherosclerosis, dendritic cell, inflammation, interleukin-10, necrosis
Référence
Circ Res. 2017 07 21;121(3):234-243