Ghrelin knockout mice display defective skeletal muscle regeneration and impaired satellite cell self-renewal.
Fiche publication
Date publication
octobre 2018
Journal
Endocrine
Auteurs
Membres identifiés du Cancéropôle Est :
Dr TOMASETTO Catherine
Tous les auteurs :
Angelino E, Reano S, Bollo A, Ferrara M, De Feudis M, Sustova H, Agosti E, Clerici S, Prodam F, Tomasetto CL, Graziani A, Filigheddu N
Lien Pubmed
Résumé
Muscle regeneration depends on satellite cells (SCs), quiescent precursors that, in consequence of injury or pathological states such as muscular dystrophies, activate, proliferate, and differentiate to repair the damaged tissue. A subset of SCs undergoes self-renewal, thus preserving the SC pool and its regenerative potential. The peptides produced by the ghrelin gene, i.e., acylated ghrelin (AG), unacylated ghrelin (UnAG), and obestatin (Ob), affect skeletal muscle biology in several ways, not always with overlapping effects. In particular, UnAG and Ob promote SC self-renewal and myoblast differentiation, thus fostering muscle regeneration.
Mots clés
Ghrelin knockout, Satellite cells, Self-renewal, Skeletal muscle regeneration
Référence
Endocrine. 2018 10;62(1):129-135