Epigenetic Regulation of the Kappa Opioid Receptor by Child Abuse.
Fiche publication
Date publication
novembre 2018
Journal
Biological psychiatry
Auteurs
Membres identifiés du Cancéropôle Est :
Dr LUTZ Pierre-Eric
Tous les auteurs :
Lutz PE, Gross JA, Dhir SK, Maussion G, Yang J, Bramoulle A, Meaney MJ, Turecki G
Lien Pubmed
Résumé
Experiences of abuse and neglect during childhood are major predictors of the emergence of depressive and suicidal behaviors throughout life. The underlying biological mechanisms, however, remain poorly understood. Here, we focused on the opioid system as a potential brain substrate mediating these effects.
Mots clés
Child abuse, DNA hydroxymethylation, DNA methylation, Kappa opioid receptor, Postmortem, Reporter assay
Référence
Biol Psychiatry. 2018 11 15;84(10):751-761