Rat BMSC infusion was unable to ameliorate inflammatory injuries in tissues of mice with LPS-induced endotoxemia.
Fiche publication
Date publication
janvier 2017
Journal
Bio-medical materials and engineering
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DE ISLA Natalia
Tous les auteurs :
Xie X, Liu H, Wu J, Chen Y, Yu Z, De Isla N, He X, Li Y
Lien Pubmed
Résumé
Mesenchymal stem cells (MSC) have been shown to have potent immunoregulatory effects. They are able to mitigate inflammation in many contexts of immune disorders, including autoimmune diseases and graft-versus-host disease (GVHD). Endotoxemia can induce systematic inflammation in the body. In this study, we try to investigate whether MSC can attenuate inflammation in models of LPS-induced endotoxemia.
Mots clés
Mesenchymal stem cells, endotoxemia, inflammation
Référence
Biomed Mater Eng. 2017 ;28(s1):S129-S138