[Chondrocyte mecanobiology. Application in cartilage tissue engineering].
Fiche publication
Date publication
novembre 2005
Journal
Bulletin de l'Academie nationale de medecine
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DE ISLA Natalia
Tous les auteurs :
Stoltz JF, Netter P, Huselstein C, de Isla N, Wei Yang J, Muller S
Lien Pubmed
Résumé
Cartilage is a hydrated connective tissue that withstands and distributes mechanical forces within joints. Chondrocytes utilize mechanical signals to maintain cartilaginous tissue homeostasis. They regulate their metabolic activity through complex biological and biophysical interactions with the extracellular matrix (ECM). Some mechanotransduction mechanisms are known, while many others no doubt remain to be discovered. Various aspects of chondrocyte mechanobiology have been applied to tissue engineering, with the creation of replacement tissue in vitro from bioresorbable or non-bioresorbable scaffolds and harvested cells. The tissues are maintained in a near-physiologic mechanical and biochemical environment. This paper is an overview of both chondrocyte mechanobiology and cartilage tissue engineering
Mots clés
Cartilage, Articular, physiology, Chondrocytes, physiology, Homeostasis, physiology, Humans, Tissue Engineering
Référence
Bull. Acad. Natl. Med.. 2005 Nov;189(8):1803-14; discussion 1814-6