Tip60 complex binds to active Pol II promoters and a subset of enhancers and co-regulates the c-Myc network in mouse embryonic stem cells.
Fiche publication
Date publication
janvier 2015
Journal
Epigenetics & chromatin
Auteurs
Membres identifiés du Cancéropôle Est :
Dr TORA Laszlo
Tous les auteurs :
Ravens S, Yu C, Ye T, Stierle M, Tora L
Lien Pubmed
Résumé
Tip60 (KAT5) is the histone acetyltransferase (HAT) of the mammalian Tip60/NuA4 complex. While Tip60 is important for early mouse development and mouse embryonic stem cell (mESC) pluripotency, the function of Tip60 as reflected in a genome-wide context is not yet well understood.
Référence
Epigenetics Chromatin. 2015 ;8:45