Multicellular cuddling in a stem cell niche.
Fiche publication
Date publication
janvier 2015
Journal
Cell adhesion & migration
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GOETZ Jacky
Tous les auteurs :
Hidalgo A, Goetz JG
Lien Pubmed
Résumé
Haematopoietic stem and progenitor cells (HSPCs) can self-renew and differentiate in any blood cell type throughout life and thereby sustain the entire blood system. To do so, HSPCs had been shown to seed, in a multi-step process, intermediate haematopoietic niches before colonizing the adult marrow. While HSPC birth had been thoroughly characterized in the past, both in mammals and in zebrafish, how perivascular niches could host HSPCs and sustain their expansion was poorly understood. In an article published in the last issue of Cell, Tamplin et al. (1) elegantly exploited the many advantages provided by the zebrafish embryo to describe how endothelium remodeling in the perivascular niche, referred to as "cuddling," favors HSPCs colonization and expansion.
Mots clés
Animals, Endothelium, physiology, Hematopoietic Stem Cells, cytology, Zebrafish, embryology
Référence
Cell Adh Migr. 2015 ;9(4):280-2