Influence of Surface Charge and Polymer Coating on Internalization and Biodistribution of Polyethylene Glycol-Modified Iron Oxide Nanoparticles.
Fiche publication
Date publication
janvier 2015
Journal
Journal of biomedical nanotechnology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MILLOT Nadine
Tous les auteurs :
Maurizi L, Papa AL, Dumont L, Bouyer F, Walker P, Vandroux D, Millot N
Lien Pubmed
Résumé
The aim of this study was to investigate the influence of the surface charge and coating of Superparamagnetic Iron Oxide Nanoparticles (SPIONs) on their in vitro and in vivo behaviors. Neutral and negatively-charged PEG-based SPIONs were synthesized and compared to Resovist, a carboxydextran-based SPION currently used in clinics. Their cytotoxicity, cell internalization, and potential as contrast agents for magnetic resonance imaging were assessed. Neutral pegylated SPIONs were internalized less readily by the reticuloendothelial system and showed a lower uptake by the liver, compared to negatively-charged SPIONs (with carboxydextran and PEG). These results suggested that the charge of functionalized SPIONs was more relevant for their biological interactions than the nature of their coating.
Mots clés
Animals, Cell Line, Cell Survival, drug effects, Coated Materials, Biocompatible, chemistry, Dextrans, administration & dosage, Hep G2 Cells, Humans, Macrophages, drug effects, Magnetite Nanoparticles, administration & dosage, Materials Testing, Mice, Nanocapsules, chemistry, Organ Specificity, Particle Size, Polyethylene Glycols, chemistry, Static Electricity, Structure-Activity Relationship, Tissue Distribution
Référence
J Biomed Nanotechnol. 2015 Jan;11(1):126-36