Application potential of mesenchymal stem cells derived from Wharton's jelly in liver tissue engineering.
Fiche publication
Date publication
janvier 2015
Journal
Bio-medical materials and engineering
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DE ISLA Natalia
Tous les auteurs :
Zhang L, Zhao YH, Guan Z, Ye JS, de Isla N, Stoltz JF
Lien Pubmed
Résumé
The shortage of organ resource has been limiting the application of liver transplantation. Bioartificial liver construction is increasingly focused as a replacement treatment. To product a bioartificial liver, three elements must be considered: seeding cells, scaffold and bioreactor. Recent studies have shown that several methods can successfully differentiate MSC (mesenchymal stem cells) derived from Wharton's jelly into hepatocyte, such as stimulating MSC by cytokines and growth factors, direct and indirect co-culture MSC with hepatocytes, or promote MSC differentiation by 3-dimensional matrix. In some cases, differentiation of MSC into hepatocytes can also be an alternative approach for whole organ transplantation in treatment of acute and chronic liver diseases. In this review, the characterization of MSC from Wharton's jelly, their potential of application in liver tissue engineering on base of decellularized scaffold, their status of banking and their preclinical work performed will be discussed.
Mots clés
Bioreactors, Cell Differentiation, physiology, Cells, Cultured, Humans, Liver, Artificial, Mesenchymal Stem Cell Transplantation, instrumentation, Mesenchymal Stromal Cells, cytology, Organ Culture Techniques, instrumentation, Prosthesis Design, Tissue Engineering, instrumentation, Tissue Scaffolds, Wharton Jelly, cytology
Référence
Biomed Mater Eng. 2015 ;25(1 Suppl):137-43