The p190 RhoGAPs, ARHGAP35, and ARHGAP5 are implicated in GnRH neuronal development: Evidence from patients with idiopathic hypogonadotropic hypogonadism, zebrafish, and in vitro GAP activity assay.
Fiche publication
Date publication
septembre 2022
Journal
Genetics in medicine : official journal of the American College of Medical Genetics
Auteurs
Membres identifiés du Cancéropôle Est :
Dr NAMBOT Sophie
Tous les auteurs :
Lippincott MF, Xu W, Smith AA, Miao X, Lafont A, Shennib O, Farley GJ, Sabbagh R, Delaney A, Stamou M, Plummer L, Salnikov K, Georgopoulos NA, Mericq V, Quinton R, Mau-Them FT, Nambot S, Hamad A, Brittain H, Tooze RS, Calpena E, Wilkie AOM, Willems M, Crowley WF, Balasubramanian R, Lamarche-Vane N, Davis EE, Seminara SB
Lien Pubmed
Résumé
The study aimed to identify novel genes for idiopathic hypogonadotropic hypogonadism (IHH).
Mots clés
Developmental disorder, Idiopathic hypogonadotropic hypogonadism, Intellectual disability, Puberty, Rho GTPase–activating protein
Référence
Genet Med. 2022 09 29;: