Role of retinoic acid receptor (RAR) signaling in post-natal male germ cell differentiation.
Fiche publication
Date publication
février 2015
Journal
Biochimica et biophysica acta
Auteurs
Membres identifiés du Cancéropôle Est :
Dr TELETIN Marius, Dr GHYSELINCK Norbert, Dr MARK Manuel
Tous les auteurs :
Mark M, Teletin M, Vernet N, Ghyselinck NB
Lien Pubmed
Résumé
All-trans retinoic acid (atRA), the active metabolite of vitamin A, plays critical functions in spermatogenesis, a complex, highly organized and regulated process comprising three phases. During the proliferative phase, undifferentiated spermatogonia divide to maintain a stem cell population and expand a progenitor cell population, of which a fraction enters the differentiation pathway yielding primary spermatocytes. During the meiotic phase, primary spermatocytes undergo recombination, segregation and reduction by half of chromosomes to produce haploid round spermatids. During the morphogenetic, post-meiotic phase, spermatids differentiate and elongate to ultimately form spermatozoa. Studies performed during the past 20 years have significantly improved our knowledge on the location of the proteins transducing the atRA signal, on the target genes of atRA and on its mechanism of action. This article is part of a Special Issue entitled: Nuclear receptors in animal development.
Mots clés
Animals, Male, Receptors, Retinoic Acid, physiology, Sertoli Cells, cytology, Signal Transduction, drug effects, Spermatogenesis, Spermatogonia, cytology, Tretinoin, pharmacology
Référence
Biochim. Biophys. Acta. 2015 Feb;1849(2):84-93