Intasome architecture and chromatin density modulate retroviral integration into nucleosome.
Fiche publication
Date publication
février 2015
Journal
Retrovirology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr RUFF Marc
Tous les auteurs :
Benleulmi MS, Matysiak J, Henriquez DR, Vaillant C, Lesbats P, Calmels C, Naughtin M, Leon O, Skalka AM, Ruff M, Lavigne M, Andreola ML, Parissi V
Lien Pubmed
Résumé
Retroviral integration depends on the interaction between intasomes, host chromatin and cellular targeting cofactors as LEDGF/p75 or BET proteins. Previous studies indicated that the retroviral integrase, by itself, may play a role in the local integration site selection within nucleosomal target DNA. We focused our study on this local association by analyzing the intrinsic properties of various retroviral intasomes to functionally accommodate different chromatin structures in the lack of other cofactors.
Mots clés
Chromatin, metabolism, DNA, metabolism, Host-Pathogen Interactions, Humans, Integrases, metabolism, Nucleosomes, metabolism, Retroviridae, physiology, Virus Integration
Référence
Retrovirology. 2015 Feb;12:13