Development of skeletal muscle atrophy and intermuscular adipose tissue in early breast cancer patients treated with chemotherapy.
Fiche publication
Date publication
septembre 2022
Journal
American journal of physiology. Cell physiology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr PIVOT Xavier, Dr SCHOTT Roland, Dr BENDER Laura, Pr FAVRET Fabrice, Dr HUCTEAU Elyse, Dr MALLARD Joris
Tous les auteurs :
Mallard J, Hucteau E, Bender L, Charlot A, Debrut L, Pflumio C, Trensz P, Schott R, Favret F, Pivot X, Hureau TJ, Pagano AF
Lien Pubmed
Résumé
Chemotherapy is a common therapy to treat breast cancer patients but also leads to skeletal muscle deconditioning. Skeletal muscle deconditioning is multifactorial and intermuscular adipose tissue (IMAT) accumulation is closely linked to muscle dysfunction. To date, there is no clinical study available investigating IMAT development through a longitudinal protocol and the underlying mechanisms remain unknown. Our study was dedicated to investigating IMAT content in early breast cancer patients treated with chemotherapy and exploring the subsequent cellular mechanisms involved in its development.
Mots clés
Fatty Infiltrations, Fibro-Adipogenic Progenitors (FAPs), IMAT, Muscle Architecture, Skeletal Muscle Deconditioning
Référence
Am J Physiol Cell Physiol. 2022 09 12;: