Oncogenic and Stemness Signatures of the High-Risk HCMV Strains in Breast Cancer Progression.
Fiche publication
Date publication
septembre 2022
Journal
Cancers
Auteurs
Membres identifiés du Cancéropôle Est :
Pr HERBEIN Georges
Tous les auteurs :
El Baba R, Pasquereau S, Haidar Ahmad S, Diab-Assaf M, Herbein G
Lien Pubmed
Résumé
Human cytomegalovirus (HCMV) oncomodulation, molecular mechanisms, and ability to support polyploid giant cancer cells (PGCCs) generation might underscore its contribution to oncogenesis, especially breast cancers. The heterogeneity of strains can be linked to distinct properties influencing the virus-transforming potential, cancer types induced, and patient's clinical outcomes.
Mots clés
CTH cells, HCMV strains, PGCCs, TNBC, ganciclovir, human cytomegalovirus, oncogenesis, paclitaxel
Référence
Cancers (Basel). 2022 09 1;14(17):