Stem cells increase in numbers in perinecrotic areas in human renal cancer.
Fiche publication
Date publication
février 2015
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
Auteurs
Membres identifiés du Cancéropôle Est :
Pr FEUGEAS Jean-Paul
Tous les auteurs :
Varna M, Gapihan G, Feugeas JP, Ratajczak P, Tan S, Ferreira I, Leboeuf C, Setterblad N, Duval A, Verine J, Germain S, Mongiat-Artus P, Janin A, Bousquet G
Lien Pubmed
Résumé
Developing strategies to overcome resistance to sunitinib is a major challenge in human renal cell carcinoma (RCC). We hypothesized that sunitinib-induced tumor necrosis-associated hypoxia could interact with renal cancer stem cells in patients with metastatic RCC.
Mots clés
Animals, Antineoplastic Agents, therapeutic use, Carcinoma, Renal Cell, drug therapy, Drug Resistance, Neoplasm, physiology, Humans, Indoles, therapeutic use, Kidney Neoplasms, drug therapy, Mice, Mice, Nude, Necrosis, Neoplastic Stem Cells, drug effects, Pyrroles, therapeutic use, Sunitinib, Xenograft Model Antitumor Assays
Référence
Clin. Cancer Res.. 2015 Feb 15;21(4):916-24