Factors predicting statin initiation during childhood in familial hypercholesterolemia: importance of genetic diagnosis.
Fiche publication
Date publication
août 2022
Journal
The Journal of pediatrics
Auteurs
Membres identifiés du Cancéropôle Est :
Pr COTTIN Yves
Tous les auteurs :
Peretti N, Vimont A, Mas E, Ferrières J, Tounian P, Lemale J, Boccara F, Di Filippo M, Charriere S, P M, Poinsot P, Cottin Y, Ducluzeau PH, Dourmap C, Cariou B, Farnier M, Paillard F, Pradignac A, Yelnik C, Gallo A, Bruckert E, Beliard S,
Lien Pubmed
Résumé
To identify childhood and parental factors associated with statin initiation in children with heterozygous familial hypercholesterolemia (HeFH), including underlying genetic diagnosis or parental premature atherosclerotic cardiovascular disease (ASCVD) STUDY DESIGN: We conducted a multicenter cohort study including 245 HeFH child-parent pairs (National register REFERCHOL; 2014 to 2020). Demographic and clinical characteristics at the last visit were collected. Vascular disease in parents was defined as a history of ASCVD, and/or a coronary artery calcium score above 100, and/or at least one carotid stenosis (>50%). Statistical analysis included descriptive analysis, logistic regression for univariate and multivariate effects of statins, and a sensitivity analysis combining the characteristics of children and parents.
Mots clés
Atherosclerotic cardiovascular disease, Cardiovascular risk, Children, Familial hypercholesterolemia, Genetic, LDL, Risk factor, Statin, Treatment
Référence
J Pediatr. 2022 08 29;: