Context-dependent function of TSLP and IL-1β in skin allergic sensitization and atopic march.
Fiche publication
Date publication
septembre 2022
Journal
Nature communications
Auteurs
Membres identifiés du Cancéropôle Est :
Dr OULAD-ABDELGHANI Mustapha , Dr LI Mei
Tous les auteurs :
Segaud J, Yao W, Marschall P, Daubeuf F, Lehalle C, German B, Meyer P, Hener P, Hugel C, Flatter E, Guivarch M, Clauss L, Martin SF, Oulad-Abdelghani M, Li M
Lien Pubmed
Résumé
Atopic diseases, including atopic dermatitis (AD) and asthma, affect a large proportion of the population, with increasing prevalence worldwide. AD often precedes the development of asthma, known as the atopic march. Allergen sensitization developed through the barrier-defective skin of AD has been recognized to be a critical step leading to asthma, in which thymic stromal lymphopoietin (TSLP) was previously shown to be critical. In this study, using a laser-assistant microporation system to disrupt targeted skin layers for generating micropores at a precise anatomic depth of mouse skin, we model allergen exposure superficially or deeply in the skin, leading to epicutaneous sensitization or dermacutaneous sensitization that is associated with a different cytokine microenvironment. Our work shows a differential requirement for TSLP in these two contexts, and identifies an important function for IL-1β, which is independent of TSLP, in promoting allergen sensitization and subsequent allergic asthma.
Référence
Nat Commun. 2022 09 1;13(1):4703