Carbamylation of Integrin : The Mechanistic Link to Platelet Dysfunction in ESKD.
Fiche publication
Date publication
août 2022
Journal
Journal of the American Society of Nephrology : JASN
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GILLERY Philippe
Tous les auteurs :
Binder V, Chruścicka-Smaga B, Bergum B, Jaisson S, Gillery P, Sivertsen J, Hervig T, Kaminska M, Tilvawala R, Nemmara VV, Thompson PR, Potempa J, Marti HP, Mydel P
Lien Pubmed
Résumé
Bleeding diatheses, common among patients with ESKD, can lead to serious complications, particularly during invasive procedures. Chronic urea overload significantly increases cyanate concentrations in patients with ESKD, leading to carbamylation, an irreversible modification of proteins and peptides.
Mots clés
carbamylation, chronic hemodialysis, chronic kidney failure, coagulation, end stage renal disease, platelets, protein carbamylation, uremia
Référence
J Am Soc Nephrol. 2022 08 29;: