Radiolabeled dendritic probes as tools for high in vivo tumor targeting: application to melanoma.
Fiche publication
Date publication
mars 2015
Journal
Journal of materials chemistry. B
Auteurs
Membres identifiés du Cancéropôle Est :
Dr FELDER-FLESCH Delphine
Tous les auteurs :
Parat A, Kryza D, Degoul F, Taleb J, Viallard C, Janier M, Garofalo A, Bonazza P, Heinrich-Balard L, Cohen R, Miot-Noirault E, Chezal JM, Billotey C, Felder-Flesch D
Lien Pubmed
Résumé
In bioimaging, targeting allows refining the diagnosis by improving the sensitivity and especially the specificity for an earlier diagnosis. Two In-radiolabeled dendritic nanoprobes (DPs) (In-2, In-3) and their model counterparts (In-1, In-4) are designed and assessed for in vitro and in vivo tumor targeting efficiency in a murine melanoma models. Tumor uptake is correlated to dendrimer multivalency and reaches values as high as 12.7 ± 1.6% ID g at 4 h post intravenous injection for In-3vs. 1.5 ± 0.5% ID g for the unfunctionalized DP, and over 11% ID g for any tumor weight whatsoever.
Référence
J Mater Chem B. 2015 Mar 28;3(12):2560-2571