Anti-tumoral effect of Thymelaea hirsuta L. extracts in colorectal cancer cells.
Fiche publication
Date publication
août 2022
Journal
Anti-cancer agents in medicinal chemistry
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MARTINY Laurent, Pr DEVARENNE-CHARPENTIER Emmanuelle, Dr EL BTAOURI Hassan
Tous les auteurs :
Toumi I, Yatouji S, Borie N, Remy S, Renault JH, Chazee L, Hammami M, Martiny L, Devarenne-Charpentier E, Btaouri HE
Lien Pubmed
Résumé
Conventional chemotherapeutic treatment of colorectal cancer has a low efficacity because of its high toxicity. Several studies identified natural compounds as potential antitumor agents by inducing cancer cell cycle arrest or apoptosis and by exhibiting a potential synergy in drug combination therapy. Natural compounds derived from plants represent an important source of pharmacologic agents toward several diseases. For example, the Tunisian Thymelaeaceae plants, are used in folk medicine for the treatment of different pathologies such as diabetes and hypertension.
Mots clés
5-Fluoruracil, Thymelaea hirsuta, apoptosis., colorectal cancer cells, natural compounds
Référence
Anticancer Agents Med Chem. 2022 08 26;: