Signalling pathways involved in the process of mesenchymal stem cells differentiating into hepatocytes.
Fiche publication
Date publication
avril 2015
Journal
Cell proliferation
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DE ISLA Natalia
Tous les auteurs :
Ye JS, Su XS, Stoltz JF, de Isla N, Zhang L
Lien Pubmed
Résumé
End-stage liver disease can be the termination of acute or chronic liver diseases, with manifestations of liver failure; transplantation is currently an effective treatment for these. However, transplantation is severely limited due to the serious lack of donors, expense, graft rejection and requirement of long-term immunosuppression. Mesenchymal stem cells (MSCs) have attracted considerable attention as therapeutic tools as they can be obtained with relative ease and expanded in culture, along with features of self-renewal and multidirectional differentiation. Many scientific groups have sought to use MSCs differentiating into functional hepatocytes to be used in cell transplantation with liver tissue engineering to repair diseased organs. In most of the literature, hepatocyte differentiation refers to use of various additional growth factors and cytokines, such as hepatocyte growth factor (HGF), fibroblast growth factor (FGF), epidermal growth factor (EGF), oncostatin M (OSM) and more, and most are involved in signalling pathway regulation and cell-cell/cell-matrix interactions. Signalling pathways have been shown to play critical roles in embryonic development, tumourigenesis, tumour progression, apoptosis and cell-fate determination. However, mechanisms of MSCs differentiating into hepatocytes, particularly signalling pathways involved, have not as yet been completely illustrated. In this review, we have focused on progress of signalling pathways associated with mesenchymal stem cells differentiating into hepatocytes along with the stepwise differentiation procedure.
Mots clés
Cell Differentiation, physiology, Cell Proliferation, Cell- and Tissue-Based Therapy, End Stage Liver Disease, therapy, Hepatocytes, cytology, Humans, Liver, metabolism, Mesenchymal Stem Cell Transplantation, Mesenchymal Stromal Cells, cytology, Signal Transduction, Tissue Engineering
Référence
Cell Prolif.. 2015 Apr;48(2):157-65