Identification of early-induced broadly neutralizing activities against transmitted founder HIV strains.
Fiche publication
Date publication
août 2022
Journal
AIDS (London, England)
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BAHRAM Siamak
Tous les auteurs :
Lucas J, Lin LY, Paul N, Laumond G, Klingler J, Schmidt S, Frappier J, Essat A, Meyer L, Gordon AC, Goujard C, Bahram S, Moog C,
Lien Pubmed
Résumé
: Broadly neutralizing antibodies (bnAbs) have been proposed as key actors for HIV vaccine development. However, they display features of highly matured Abs, hampering their induction by vaccination. As protective bnAbs should be induced rapidly after vaccination and should neutralize the early-transmitted founder (T/F) viruses, we searched whether such Abs may be induced following HIV infection.
Référence
AIDS. 2022 08 24;: