Circulating DNA as a Strong Multimarker Prognostic Tool for Metastatic Colorectal Cancer Patient Management Care.
Fiche publication
Date publication
juin 2016
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BIBEAU Frédéric
Tous les auteurs :
El Messaoudi S, Mouliere F, Du Manoir S, Bascoul-Mollevi C, Gillet B, Nouaille M, Fiess C, Crapez E, Bibeau F, Theillet C, Mazard T, Pezet D, Mathonnet M, Ychou M, Thierry AR
Lien Pubmed
Résumé
Circulating cell-free DNA (ccfDNA) is a valuable source of tumor material obtained from a simple blood sampling that enables noninvasive analysis of the tumor genome. Our goal was to carry out a multiparametric analysis of ccfDNA and evaluate its prognostic value by investigating the overall survival (OS) of 97 metastatic colorectal cancer patients (mCRC).
Mots clés
Adult, Aged, Aged, 80 and over, Biomarkers, Tumor, blood, Cell-Free Nucleic Acids, blood, Colorectal Neoplasms, blood, DNA Fragmentation, DNA, Neoplasm, blood, Female, Gene Frequency, genetics, Humans, Male, Middle Aged, Polymerase Chain Reaction, Prognosis, Proto-Oncogene Proteins B-raf, genetics, Proto-Oncogene Proteins p21(ras), genetics
Référence
Clin Cancer Res. 2016 06 15;22(12):3067-77