Fatty acid desaturase genetic variations and dietary omega-3 fatty acid intake associate with arterial stiffness.
Fiche publication
Date publication
mars 2022
Journal
European heart journal open
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BEHM-ANSMANT Isabelle, Dr BRANLANT Christiane, Pr ROSSIGNOL Patrick
Tous les auteurs :
Bäck M, Xhaard C, Rouget R, Thuillier Q, Plunde O, Larsson SC, Girerd N, Ferreira JP, Boivin JM, Bozec E, Mercklé L, Zannad F, Hoge A, Guillaume M, Dandine-Roulland C, Floch EL, Bacq-Daian D, Deleuze JF, Van den Berghe L, Nazare JA, Laville M, Branlant C, Behm-Ansmant I, Wagner S, Rossignol P
Lien Pubmed
Résumé
Long-chain polyunsaturated fatty acids (PUFAs) generate diverse bioactive lipid mediators, which tightly regulate vascular inflammation. The effects of omega-3 PUFA supplementation in cardiovascular prevention however remain controversial. In addition to direct dietary intake, fatty acid desaturases (FADS) determine PUFA levels. Increased arterial stiffness represents an independent predictor of mortality and cardiovascular events. The aim of the present study was to determine the association of PUFA intake, FADS1 genotype, and FADS expression with arterial stiffness.
Mots clés
Arterial stiffness, Dietary, Inflammation, Omega-3 fatty acids, Prevention, STANISLAS cohort
Référence
Eur Heart J Open. 2022 03;2(2):oeac016