Unravelling the etiology of sporadic late-onset cerebellar ataxia in a cohort of 205 patients: a prospective study.
Fiche publication
Date publication
juillet 2022
Journal
Journal of neurology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr NAMER Izzie-Jacques, Pr CHELLY Jamel
Tous les auteurs :
Bogdan T, Wirth T, Iosif A, Schalk A, Montaut S, Bonnard C, Carre G, Lagha-Boukbiza O, Reschwein C, Albugues E, Demuth S, Landsberger H, Einsiedler M, Parratte T, Nguyen A, Lamy F, Durand H, Fahrer P, Voulleminot P, Bigaut K, Chanson JB, Nicolas G, Chelly J, Cazeneuve C, Koenig M, Bund C, Namer IJ, Kremer S, Calmels N, Tranchant C, Anheim M
Lien Pubmed
Résumé
Despite recent progress in the field of genetics, sporadic late-onset (> 40 years) cerebellar ataxia (SLOCA) etiology remains frequently elusive, while the optimal diagnostic workup still needs to be determined. We aimed to comprehensively describe the causes of SLOCA and to discuss the relevance of the investigations.
Mots clés
Brain MRI, Genetics, I123-ioflupane SPECT, Late-onset cerebellar ataxia, Multiple system atrophy
Référence
J Neurol. 2022 07 23;: