New derivatives from the aerial parts of Boerhaavia diffusa L. (Nyctaginaceae).
Fiche publication
Date publication
novembre 2013
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GUILLAUME Dominique
Tous les auteurs :
Do TML, Truong AV, Vo TN, Pinnock TG, Pratt LM, Guillaume D, Nguyen KPP
Lien Pubmed
Résumé
Boerhaavia diffusa L. is used in the traditional medicine of several Asian countries. The isolation and identification of five new compounds, together with 11 known compounds, from the ethyl acetate extract of the aerial part of B. diffusa grown Vietnam is reported. The structure of the new compounds was established by 1D and 2D NMR spectroscopy, and high resolution ESI-MS analysis. New compounds are two rotenoids: 9,11-dihydroxy-6,10-dimethoxy[1] benzopyrano[3,4-b][1] benzopyran-12(6H)-one (boeravinone P, 3) and 3-[2-(beta-D-glucopyranosyloxy)-3-hydroxyphenyl]-5-hydroxy-2-hydroxymethyl-7-methoxy-6-methyl-4H-1-benzopyran-4-one (boeravinone Q, 9), an atropisomeric mixture of two rotenoid glycosides (30,5-dihydroxy-2-hydroxymethyl-7-methoxy-6-methylisoflavone 2'-O-beta-D-glucopyranoside, 11), a sesquiterpene lactone (4,10-dihydroxy-8-methoxyguai-7(11)-en-8,12-olide, 5) and a new phenylpropanoid glycoside (boerhaavic acid, 15). (C) 2013 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
Référence
Phytochem Lett. 2013 Nov;6(4):544-51.