Hairy lymphoproliferations: a case report and review of the literature
Fiche publication
Date publication
juin 2022
Journal
Annales de biologie clinique
Auteurs
Membres identifiés du Cancéropôle Est :
Dr LESESVE Jean-François, Pr BROSEUS Julien
Tous les auteurs :
Julien M, Latger-Cannard V, Salignac S, Aubert C, Gérard D, Broseus J, Lesesve JF
Lien Pubmed
Résumé
Mature B-cell lymphoproliferation with hairy lymphocytes include Marginal Zone Splenic Lymphoma (SMZL), Hairy Cell Leukemia (HCL), Splenic Diffuse Red Pulp Lymphoma (SDRPL), and Variant Hairy Cell Leukemia (HCL-v), the two latter being provisional entities that appeared in the 2008 WHO classification. We report the case of a 75-year-old man who benefited from a diagnostic re-evaluation of his SMZL. The good clinical evolution, the flow cytometry investigation (HCL score < 3, SDRPL score > 3, strong CD180 and CD200/CD180 ratio < 0.5) and the histological assessment favored a SDRPL. This entity did not exist at the time of the diagnosis in 2006. The differential diagnosis between these diseases sometimes remains uneasy. Here are mentioned some practical clues to assess the diagnosis.
Mots clés
villous lymphocyte, immunophenotyping, SMZL, HCL, HCL-v, SDRPL
Référence
Ann Biol Clin (Paris). 2022 06 30;80(3):252-258