Computational approaches for simulating luminogenesis.
Fiche publication
Date publication
juin 2022
Journal
Seminars in cell & developmental biology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr RIVELINE Daniel
Tous les auteurs :
Fuji K, Tanida S, Sano M, Nonomura M, Riveline D, Honda H, Hiraiwa T
Lien Pubmed
Résumé
Lumens, liquid-filled cavities surrounded by polarized tissue cells, are elementary units involved in the morphogenesis of organs. Theoretical modeling and computations, which can integrate various factors involved in biophysics of morphogenesis of cell assembly and lumens, may play significant roles to elucidate the mechanisms in formation of such complex tissue with lumens. However, up to present, it has not been documented well what computational approaches or frameworks can be applied for this purpose and how we can choose the appropriate approach for each problem. In this review, we report some typical lumen morphologies and basic mechanisms for the development of lumens, focusing on three keywords - mechanics, hydraulics and geometry - while outlining pros and cons of the current main computational strategies. We also describe brief guidance of readouts, i.e., what we should measure in experiments to make the comparison with the model's assumptions and predictions.
Mots clés
Computational approaches, Luminogenesis, Mathematical modeling
Référence
Semin Cell Dev Biol. 2022 06 27;: