miRNAs at the heart of host-pathogen interactions.
Fiche publication
Date publication
novembre 2013
Auteurs
Membres identifiés du Cancéropôle Est :
Dr PFEFFER Sébastien
Tous les auteurs :
Contrant M, Fender A, Pfeffer S
Lien Pubmed
Résumé
MicroRNAs are small regulators found in almost all eukaryotes. They are involved in key cellular process such as tissue differentiation or cell cycle regulation. Interestingly, some viruses encode their own set of miRNA genes. Viral miRNAs can act in cis by targeting the viral genome or in trans by affecting the expression of host mRNAs. Thus, be they viral or cellular, miRNAs are at the heart of host-pathogen interactions. In this review, we first present the viruses that encode miRNAs and how these are expressed in the host cells. Second, we describe the biological roles of viral and cellular miRNAs during infection by several representative examples. This domain of investigation has seen tremendous interest in the past few years, and might lead to the development of new therapeutics in a near future.
Référence
Virologie. 2013 Nov-dec;17(6):414-25.