Neuro- and Cardiovascular Activities of Snake Venom.
Fiche publication
Date publication
juin 2022
Journal
Biology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr KREZEL Wojciech
Tous les auteurs :
Sahyoun C, Krezel W, Mattei C, Sabatier JM, Legros C, Fajloun Z, Rima M
Lien Pubmed
Résumé
The complications following snake bite envenoming are due to the venom's biological activities, which can act on different systems of the prey. These activities arise from the fact that snake venoms are rich in bioactive molecules, which are also of interest for designing drugs. The venom of , known as the Lebanon viper, has been shown to exert antibacterial, anticancer, and immunomodulatory effects. However, the venom's activity on the nervous system has not yet been studied, and its effect on the cardiovascular system needs further investigation. Because zebrafish is a convenient model to study tissue alterations induced by toxic agents, we challenged it with the venom of . We show that this venom leads to developmental toxicity but not teratogenicity in zebrafish embryos. The venom also induces neurotoxic effects and disrupts the zebrafish cardiovascular system, leading to heartbeat rate reduction and hemorrhage. Our findings demonstrate the potential neurotoxicity and cardiotoxicity of 's venom, suggesting a multitarget strategy during envenomation.
Mots clés
Montivipera bornmuelleri, cardiotoxicity, neurotoxicity, zebrafish
Référence
Biology (Basel). 2022 06 9;11(6):