Contribution of hemodynamic side effects and associated autonomic reflexes to ventricular arrhythmias triggering by torsadogenic hERG blocking drugs.
Fiche publication
Date publication
juin 2022
Journal
British journal of pharmacology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BASTOGNE Thierry
Tous les auteurs :
Champéroux P, Fares R, Bastogne T, Richard S, Le Guennec JY, Thireau J
Lien Pubmed
Résumé
Several hERG blocking drugs known for their propensity to trigger Torsades de Pointes (TdP) were reported to induce a sympatho-vagal coactivation and to enhance High Frequency heart rate (HFHR) and QT oscillations (HFQT) from telemetric data. The present work aims to characterise the underlying mechanism(s) leading to these autonomic changes.
Mots clés
HF oscillations, QTc prolongation, Torsades de pointes, hERG channel, hemodynamic
Référence
Br J Pharmacol. 2022 06 24;: