Radionecrosis after repeated courses of radiotherapy under stereotactic conditions for brain metastases: Analysis of clinical and dosimetric data from a retrospective cohort of 184 patients.
Fiche publication
Date publication
juin 2022
Journal
Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique
Auteurs
Membres identifiés du Cancéropôle Est :
Pr ANTONI Delphine, Pr NOEL Georges, Dr CEBULA Hélène, Dr LE FEVRE Clara
Tous les auteurs :
Kuntz L, Le Fèvre C, Jarnet D, Keller A, Meyer P, Cox DG, Bund C, Antoni D, Cebula H, Noel G
Lien Pubmed
Résumé
Between 10 and 40% of patients with cancer will develop one or more brain metastases (BMs). Stereotactic radiotherapy (SRT) is part of the therapeutic arsenal for the treatment of de novo or recurrent BM. Its main interest is to delay whole brain radiation therapy (WBRT), which may cause cognitive toxicity. However, SRT is not exempt from long-term toxicity, and the most widely known SRT is radionecrosis (RN). The objective of this study was to analyze the occurrence of RN per BM and per patient.
Mots clés
Brain metastases, Métastases cérébrales, Radionecrosis, Radionécrose, Repeated radiosurgery, Réirradiation, Salvage radiation, Stereotactic radiosurgery, Stéréotaxie, Toxicity, Toxicité, Traitement de rattrapage
Référence
Cancer Radiother. 2022 06 14;: