Variability in primary Sjögren's syndrome is driven by interferon alpha, and genetically associated with the class II HLA DQ locus.
Fiche publication
Date publication
juin 2022
Journal
Arthritis & rheumatology (Hoboken, N.J.)
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MEYER Nicolas, Dr DUMORTIER Hélène, Pr GOTTENBERG Jacques-Eric
Tous les auteurs :
Trutschel D, Bost P, Mariette X, Bondet V, Llibre A, Posseme C, Charbit B, Thorball CW, Jonsson R, Lessard CJ, Felten R, Ng WF, Chatenoud L, Dumortier H, Sibilia J, Fellay J, Brokstad KA, Appel S, Tarn Dr JR, Murci LQ, Mingueneau M, Meyer N, Duffy D, Schwikowski B, Gottenberg JE,
Lien Pubmed
Résumé
Primary Sjögren's syndrome (pSS) is the second most frequent systemic autoimmune disease affecting 0.1% of the general population. To characterize the molecular and clinical variability across pSS patients, we integrated transcriptomic, proteomic, cellular and genetic data with clinical phenotypes in a cohort of 351 pSS patients.
Référence
Arthritis Rheumatol. 2022 06 20;: