Ustekinumab in Crohn's Disease: New Data for Positioning in Treatment Algorithm.
Fiche publication
Date publication
mai 2022
Journal
Journal of Crohn's & colitis
Auteurs
Membres identifiés du Cancéropôle Est :
Pr PEYRIN-BIROULET Laurent
Tous les auteurs :
D'Amico F, Peyrin-Biroulet L, Danese S
Lien Pubmed
Résumé
The treatment of patients with moderate to severe Crohn's disease [CD] is still challenging. Therapeutic options include steroids, immunosuppressants, anti-TNFα agents, vedolizumab, and ustekinumab. Ustekinumab is a monoclonal antibody blocking the p40 subunit of IL-12 and IL-23. It showed to be effective and safe in randomised clinical trials and real-life studies and is currently approved for the management of CD patients who are naive to biologics and those who have already been treated with such medications. However, to date, a detailed and approved therapeutic algorithm is not available. The aim of this review is to report the most recent and updated data on the efficacy and safety of ustekinumab for the treatment of patients with moderate to severe CD and to define the optimal management of these patients.
Mots clés
Crohn’s disease, Inflammatory bowel diseases, algorithm, ustekinumab
Référence
J Crohns Colitis. 2022 05 11;16(Supplement_2):ii30-ii41