Functionalization of theranostic AGuIX® nanoparticles for PET/MRI/optical imaging.
Fiche publication
Date publication
août 2019
Journal
RSC advances
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DENAT Franck, Dr COLLIN Bertrand, Pr ROUX Stéphane
Tous les auteurs :
Thakare V, Tran VL, Natuzzi M, Thomas E, Moreau M, Romieu A, Collin B, Courteau A, Vrigneaud JM, Louis C, Roux S, Boschetti F, Tillement O, Lux F, Denat F
Lien Pubmed
Résumé
A novel trifunctional imaging probe containing a chelator of radiometal for PET, a NIR heptamethine cyanine dye, and a bioconjugatable handle, has been grafted onto AGuIX® nanoparticles a Michael addition reaction. The resulting functionalized nanoparticles have been fully characterized, radiolabelled with Cu, and evaluated in a mice TSA tumor model using multimodal (PET/MRI/optical) imaging.
Référence
RSC Adv. 2019 Aug 8;9(43):24811-24815